Thrombin regulation in neonates undergoing cardiopulmonary bypass.
نویسندگان
چکیده
Satu Långström1, Paula Rautiainen2, Leena Mildh2, Kaija Peltola2, Ulla Wartiovaara-Kautto3, Markku Heikinheimo1,4, Jari Petäjä1,5 1Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland; 2Department of Anesthesia and Intensive Care, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland; 3Helsinki University Central Hospital Laboratory Services (HUSLAB), Department of Clinical Chemistry, Laboratory of Hematology, University of Helsinki, Finland; 4Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA; 5Department of Pediatrics, Jorvi Hospital, University of Helsinki, Espoo, Finland
منابع مشابه
Augmentation of thrombin generation in neonates undergoing cardiopulmonary bypass.
INTRODUCTION Factor concentrates are currently available and becoming increasingly used off-label for treatment of bleeding. We compared recombinant activated factor VII (rFVIIa) with three-factor prothrombin complex concentrate (3F-PCC) for the ability to augment thrombin generation (TG) in neonatal plasma after cardiopulmonary bypass (CPB). First, we used a computer-simulated coagulation mode...
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The primary function of recombinant activated factor VII (rFVIIa) is to increase thrombin formation which leads to increased fibrin and less "bleeding." As a result, most of literature utilizes "bleeding" as the outcome measure with respect to rFVIIa. However, we report the actual effect of rFVIIa on changes in hemostatic markers such as prothrombin activation peptide F1.2, thrombin antithrombi...
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BACKGROUND Antifibrinolytic medications such as ε-aminocaproic acid (EACA) are used in pediatric heart surgery to decrease surgical bleeding and transfusion. Dosing schemes for neonates are often based on adult regimens, or are simply empiric, in part due to the lack of neonatal pharmacokinetic information. The authors sought to determine the pharmacokinetics of EACA in neonates undergoing card...
متن کاملEffects of surgical trauma and cardiopulmonary bypass on active thrombin concentrations and the rate of thrombin inhibition in vivo.
The in vivo concentration of active thrombin and the second-order rate constant for the inhibition of thrombin by antithrombin (k(inh)) were estimated in patients undergoing cardiopulmonary bypass (CPB) based on measured levels of hemostatic markers in combination with a computer model of the patient's hemostatic and vascular systems. At baseline k(inh) = 0.6 +/- 0.1 microM(-1) s(-1) leaving 27...
متن کاملEstimating the rate of thrombin and fibrin generation in vivo during cardiopulmonary bypass.
Our objective was to estimate the in vivo rates of thrombin and fibrin generation to better understand how coagulation is regulated. Studied were 9 males undergoing cardiopulmonary bypass (CPB). The rates of thrombin, total fibrin, and soluble fibrin generation in vivo were based on measured levels of prothrombin activation peptide F1.2, thrombin-antithrombin complex, fibrinopeptide A, and solu...
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ورودعنوان ژورنال:
- Thrombosis and haemostasis
دوره 99 4 شماره
صفحات -
تاریخ انتشار 2008